Method for obtaining modified immunoglobulins with reduced...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2153135

A method for identifying differences in mammalian species specific amino acid residues onto T-cell antigenic sequences on an immunoglobulin includes comparing the framework amino acids of a variable domain of a first mammalian species with the variables domains of a second mammalian species; determining the subgroups of the second mammalian species to which the first mammalian species most closely corresponds; determining the second mammalian species sequence which is most similar to the first mammalian species sequence; identifying amino acid residues of the first mammalian species which differ from the amino acid residues of the second mammalian species, with said amino acids being onto T-cell antigenic sequences in the variable region of the immunoglobulins; and identifying only those amino acid residues which are not within a complementarity region or are not directly involved with canonical structures or Vernier zone.

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