Method for obtaining pure enantiomers of a pyridazinone...

Details Method for obtaining pure enantiomers of a pyridazinone... Method for obtaining pure enantiomers of a pyridazinone...

C - Chemistry, Metallurgy

07

D

C07D 237/04 (2006.01)

Patent

CA 2250062

A method for preparing optically substantially pure (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3- pyridazinyl)phenyl]hydrazono]propanedinitrile from racemic 6-(4-aminophenyl)- 4,5-dihydro-5-methyl-3(2H)-pyridazinone intermediate is described. The end product is useful as a cardiotonic agent. A novel crystalline polymorphic form of the end product is also described.

La présente invention concerne un procédé de préparation de (-)-[[4-(1,4,5,6-tétrahydro-4-méthyl-6-oxo-3-pyridazinyl)phényl]hydrazono]propanedinitrile à partir d'un intermédiaire, en l'occurrence un 6-(4-aminophényl)-4,5-dihydro-5-méthyl-3(2H)pyridazinone racémique. Le produit fini convient particulièrement comme tonicardiaque. L'invention concerne également une forme cristalline polymorphe nouvelle.

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