Method for obtaining receptor agonist antibodies

Details Method for obtaining receptor agonist antibodies Method for obtaining receptor agonist antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224174

A method is provided for generating antibodies which demonstrate the agonist properties of the naturally occuring ligand of a receptor molecule by using as an immunogen a recombinant immunogen which corresponds to a multimeric form of a receptor. In this immunogen the extracellular domains are in a similar disposition to that expected for receptors having two or more subunits on the surface of the cell.

L'invention porte sur un procédé de production d'anticorps présentant les propriétés agonistes du ligand d'origine naturelle d'une molécule réceptrice en recourant comme immunogène à un immunogène de recombinaison correspondant à une forme multimère d'un récepteur. Dans cet immunogène les domaines extracellulaires sont dans une disposition similaire à celle qu'on attend de récepteurs présentant deux sous-unités à la surface de la cellule ou davantage.

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