Method for optimally sizing cells of a centrifugal partition...

Details Method for optimally sizing cells of a centrifugal partition... Method for optimally sizing cells of a centrifugal partition...

G - Physics

01

N

G01N 30/42 (2006.01)

Patent

CA 2559546

The invention relates to a method for sizing the cells of a liquid-liquid centrifugal chromatography column (CPC column) consisting of stacked discs on which the series-connected cells are engraved by small channels. The stack rotation produces a high centrifugal acceleration field which makes it possible to maintain a liquid phase in an immobile, called stationary, state while a mobile phase flows along the CPC column. The cells are embodied in three-dimensional form in such a way that two dimensions (L, l) thereof are oriented in a plane substentially normal to the disc axis of rotation (.OMEGA.) and the third dimension (e) is oriented in a direction substentially parallel to said axis of rotation and is selected such that it is at least equal to one of two dimensions (L, l), thereby obtaining a higher efficiency. In order to scale devices, the cell sizes are modified ensuring that in any case said third dimension (e) is privileged in such a way that it is as large as possible. Said invention can be used for designing analytic or preparative chromatography devices.

Méthode pour dimensionner les cellules d'une « colonne » de chromatographie liquide-liquide centrifuge (colonne CPC) constituée de disques empilés, sur lesquels sont gravés les cellules reliées en cascade (en série) par des petits canaux. La rotation de la pile crée un champ d'accélération centrifuge important qui permet de maintenir immobile une phase liquide, dite stationnaire, tandis qu'une phase mobile circule le long de la colonne CPC. Les cellules sont tridimensionnelles avec deux dimensions (L, 1) des cellules étant orientées dans un plan sensiblement normal à l'axe de rotation (.OMEGA.) du disque et une troisième dimension (e) qui est dirigée selon une direction sensiblement parallèle à l'axe de rotation, et que l'on choisit de façon qu'elle soit au moins égale à l'une des deux autres dimensions (L, 1), ce qui procure une meilleure efficacité. Quand on doit changer l'échelle des appareils, on modifie la taille des cellules en veillant dans tous les cas à privilégier cette troisième dimension (e) qui doit être la plus grande possible. - Applications à la conception d'appareils de chromatographie analytique ou préparative.

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