C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2729591
The invention relates to a method for optimizing the biophysical properties of molecules and derivatives of the Ig superfamily. The method is characterized in that as yet unrecognized helical structural elements with unknown structural, stability and folding roles have been identified as important determinants of correct and efficient structuring of antibody domains. The novel process for positively influencing the antibody properties and properties of other proteins that have the Ig folding pattern now consists of optimizing the properties of the short helical elements and in the transplantation of these elements between Ig domains.
L'invention concerne un procédé pour l'optimisation des propriétés biophysiques de molécules et de dérivés de la superfamille des immunoglobulines. Le procédé selon l'invention est caractérisé en ce que des éléments structurels hélicoïdaux non reconnus jusqu'à présent pour leur rôle dans la structure, la stabilité et le repliement ont pu être identifiés comme déterminants essentiels de la structuration correcte et efficace de domaines d'anticorps. Le nouveau procédé visant à influer positivement sur les propriétés des anticorps et celles d'autres protéines présentant le modèle de repliement Ig consiste désormais en l'optimisation des propriétés des éléments hélicoïdaux courts et en la transplantation de ces éléments entre domaines Ig.
Ambrosius Dorothee
Buchner Johannes
Enenkel Barbara
Feige Matthias
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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