A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/506 (2006.01) A61P 35/02 (2006.01) G01N 33/60 (2006.01)
Patent
CA 2691200
The present invention relates to a method for evaluating patients to help optimizing the treatment of chronic myeloid leukemia (CML) in a human patient population. More specifically, the method comprises the steps of (a) determining the OCT-1 Activity in pre-therapy blood of a warm-blooded animal suffering from CML, and (b) administering a daily dose between about 500 and 1200 mg of Imatinib mesylate to the warm-blooded animal suffering from CML showing an OCT-1 Activity corresponding to Imatinib intracellular concentration below about 6.0 to 10.0 ng/200,000 cells, especially about 8.0 to 8.5 ng/200,000 cells.
La présente invention a pour objet un procédé d'évaluation de patients pour aider à optimiser le traitement de la leucémie chronique myéloïde (LCM) dans une population de patients humains. De manière plus spécifique, le procédé comprend les étapes consistant à (a) déterminer l'activité OCT-1 dans le sang avant le traitement d'un animal à sang chaud souffrant de LCM et (b) administrer une dose quotidienne comprise entre environ 500 et 1200 mg de mésylate d'Imatinib à l'animal à sang chaud souffrant de LCM présentant une activité OCT-1 correspondant à la concentration intracellulaire d'Imatinib inférieure à environ 6,0 à 10,0 ng/200 000 cellules, spécialement environ 8,0 à 8,5 ng/ 200 000 cellules.
Hughes Timothy Peter
White Deborah
Fetherstonhaugh & Co.
Medvet Science Pty Ltd
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