G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 24/00 (2006.01)
Patent
CA 2587588
The present invention relates to methods for optimizing therapeutic efficacy or reducing toxicity in a subject receiving any drug that can be metabolized to an active 6-mercapto-purine metabolite that has therapeutic efficacy such as 6-thioguanine nucleotide (6-TGN).Metabolic pathwaysare demonstratedon Figure 1. The methods provide determining 6-TGN and 6methylmercaptopurine nucleotide (6-MMPN) concentration levelsusing mass spectrometric methods, including LC-MS spectroscopy.
L'invention concerne des procédés pour optimiser l'efficacité thérapeutique ou réduire la toxicité chez un sujet qui prend un médicament fournissant de la 6-thioguanine nucléotide. Ces procédés consistent à déterminer les niveaux de concentration de 6-thioguanine nucléotide et de 6-méthyl-mercaptopurine nucléotide par technique analytique à source ionisante.
Fetherstonhaugh & Co.
Prometheus Laboratories Inc.
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