C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C07H 21/04 (2006.01) C07K 14/32 (2006.01) C12N 1/20 (2006.01) C12N 9/00 (2006.01) C12N 9/90 (2006.01) C12N 15/00 (2006.01) C12P 19/04 (2006.01)
Patent
CA 2479246
The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
L'invention concerne des procédés de production et de sélection de nouvelles souches de mutants de <i>B. fragilis</i> exprimant de manière constitutive un polysaccharide capsulaire spécifique ou uniquement des polysaccharides capsulaires sélectionnés; ainsi que des compositions dirigées contre les nouvelles souches de mutants de <i>B. fragilis</i> exprimant de manière constitutive un polysaccharide capsulaire spécifique ou uniquement des polysaccharides capsulaires sélectionnés; et des procédés améliorés de purification de polysaccharides capsulaires individuels et des compositions dirigées contre des nouveaux gènes res02 et inv19 et leurs produits géniques. L'invention concerne également des procédés et des compositions de surexpression et de purification de polysaccharides capsulaires immunomodulateurs A (PSA) à un rendement élevé.
Comstock Laurie E.
Coyne Michael J.
Kasper Denis L.
Tzianabos Arthur O.
Weinacht Katja G.
Brigham And Women's Hospital Inc.
Smart & Biggar
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