Method for performing prognoses for high-risk breast cancer...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2647016

A first exemplary method for performing a prognosis for a breast cancer patient, comprises the steps of determining the status of an aberration of the T0P2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient at a later time based upon a pre-determined Hazard Ratio corresponding to the determined status. A second such exemplary method comprises the steps of determining the status of an aberration of the T0P2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient at a later time based upon a pre-determined Kaplan-Meier plot corresponding to the determined status.

L'invention concerne un premier exemple de méthode de permettant d'effectuer un pronostic cancer du sein pour une patiente, comprenant les étapes consistant à déterminer l'état d'une aberration du gène T0P2A dans un échantillon de tissu prélevé chez ladite patiente ; et à estimer la probabilité soit de survie sans rechute, soit de survie globale de la patiente dans le future, sur base d'une proportion prédéterminée du risque correspondant à l'état déterminé. Un deuxième example de méthode comprend les étapes consistant à déterminer l'état d'une aberration du gène T0P2A dans un échantillon de tissu prélevé chez ladite patiente ; et à estimer la probabilité soit de survie sans rechute, soit de survie globale de la patiente dans le futur, sur base d'une courbe de Kaplan-Meier prédéterminée correspondant à l'état déterminé.

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