Method for pr-39 peptide regulated stimulation of angiogenesis

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) C07K 7/00 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 14/81 (2006.01)

Patent

CA 2368638

The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homolog, for interaction with such proteasomes as one present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with proteasomes is a decrease in the intracellular degradation of active peptides such as HIF- 1.alpha. and a consequential stimulation of angiogenesis in-situ.

La présente invention concerne à la fois une méthode et un moyen de régulation de l'angiogénèse dans des cellules vivantes, des tissus ainsi que des organes in situ. La régulation est exécutée à l'aide d'un peptide PR-39 natif ou d'un de ses homologues de longueur plus courte, afin d'avoir une interaction avec des protéasomes tels que ceux présents dans le cytoplasme de cellules viables. Le résultat de l'interaction du peptide PR-39 avec les protéasomes est une diminution de la dégradation intracellulaire de peptides actifs tels que HIF-1.alpha. et par conséquent une stimulation de l'angiogénèse in situ.

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