C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 9/10 (2006.01) C12N 15/09 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2499707
An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation (s) in a gene coding for UGT. A gene coding for UGT comprises 5 exons, and since the regions of exons 2 through 5 are common to each isoform of UGT1, by assaying a mutation in the common regions, particularly a mutation in exon 5 region, and further adding the detection of (a) mutation(s) in a plurality of exon regions, mutations of UGT1 gene can effectively assayed. A nucleic acid chip using nucleic acid probes is used as a way of detecting (a) mutation(s).
L'invention porte sur un procédé d'évaluation, estimation ou vérification du métabolisme d'un médicament par la détection de mutations effectives dans un gène codant UGT. Du fait qu'un gène codant UGT est constitué de 5 exons et que les exons 2 à 5 sont communs dans chaque isoforme d'UGT1, on vérifie des mutations effectives dans le gène UGT1 en examinant les mutations dans les régions communes (notamment, des mutations dans l'exon 5) et en détectant également des mutations dans plusieurs régions d'exons. Pour examiner les mutations, on utilise des fragments d'acide nucléique pourvus de sondes d'acide nucléique.
Fujiyama Yoshihide
Sato Hiroshi
Yamamoto Kazuo
Moffat & Co.
National University Corporation Shiga University Of Medical Scie
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