Method for predicting response to tamoxifen

Details Method for predicting response to tamoxifen Method for predicting response to tamoxifen

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2694409

This invention relates, e.g., to a method for predicting the response of a subject having, or at risk of developing, breast cancer to Tamoxifen therapy. The method comprises measuring the amount of phosphorylation at residues S70 of Bcl-2, Y992 of EGFR, and/or Y527 of Src in a suitable sample from the subject, wherein a statistically significantly elevated level of phosphorylation at one or more of the three residues compared to a baseline value indicates that the subject is likely to be responsive to Tamoxifen therapy.

La présente invention concerne, par exemple, un procédé de prédiction de la réponse d'un sujet souffrant d'un cancer du sein, ou risquant de le développer, à une thérapie à base de tamoxifène. Le procédé comprend la mesure de la quantité de phosphorylation des résidus S70 de Bcl-2, Y992 de EGFR et/ou Y527 de Src dans un échantillon approprié provenant du sujet, dans lequel un taux de phosphorylation significativement élevé sur le plan statistique d'un ou plusieurs des trois résidus par comparaison à une valeur de base indique que le sujet est probablement réactif à une thérapie à base de tamoxifène.

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