C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2670443
The present invention relates to cancer treatment and particularly to a method for predicting the response of a cancer subject to a given therapy. The invention provides a gene or gene product useful as a predictive marker for classifying the subjects. Also disclosed are diagnostic tools, test kits and compositions and their use in the method. The invention is based on the use of NAD(P)H :Quinone oxidoreductase 1, NQOl, which enables the identification and classification of subjects who would benefit from being excluded from a treatment, particularly from anthracycline-based adjuvant chemotherapy with epirubicin.
La présente invention concerne le traitement du cancer et, en particulier, un procédé pour prédire la réponse d'un sujet atteint d'un cancer à une thérapie donnée. L'invention propose un gène ou un produit génique utile comme marqueur prédictif pour classer les sujets. Sont également décrits des outils de diagnostic, des kits d'essai ainsi que des compositions et leur utilisation dans le procédé. L'invention est basée sur l'utilisation de NAD(P)H : Quinone oxydoréductase 1, NQOl, qui permet l'identification et la classification des sujets qui gagneraient à être exclus d'un traitement, en particulier d'une chimiothérapie adjuvante à base d'anthracycline comprenant l'épirubicine.
Fagerholm Rainer
Nevanlinna Heli
Tommiska Johanna
Licentia Ltd.
Ridout & Maybee Llp
LandOfFree
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