C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2668955
The present invention relates to a method for predicting the responsiveness of a patient to a treatment with a TNF-alpha blocking agent, said method comprising determining the presence or absence of a guanine at position -238, a guanine at position -308, and a cytosine at position -857 of the TNF-alpha gene of said patient, wherein the simultaneous presence of a guanine at position -238, a guanine at position -308, and a cytosine at position -857 of the TNF-alpha gene in both copies of said TNF-alpha gene of said patient is indicative of a lessened likelihood of responsiveness of said patient to a treatment with a TNF-alpha blocking agent with respect to standard responsiveness.
La présente invention porte sur un procédé permettant de prédire la sensibilité d'un patient à un traitement par un agent bloquant le TNF-alpha, ledit procédé comprenant la détermination de la présence ou de l'absence d'une guanine en position -238, d'une guanine en position -308 et d'une cytosine en position -857 du gène TNF-alpha dudit patient. La présence simultanée d'une guanine en position -238, d'une guanine en position -308 et d'une cytosine en position -857 du gène TNF-alpha dans les deux copies dudit gène TNF-alpha dudit patient est indicative d'une probabilité diminuée de sensibilité dudit patient à un traitement par un agent bloquant le TNF-alpha par rapport à une sensibilité standard.
Mariette Xavier
Miceli Corinne
Institut National de La Sante Et de La Recherche Medicale (inser
Robic
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