C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/22 (2006.01) A61K 31/55 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2594869
A process for the preparation of 10,11-dihydro-10-hydroxy-5H- dibenz/b,f/azepine-5-carboxamide (1) by ring opening of 11a,10b-dihydro-6H- dibenz/b,f/oxireno[d]azepine-6-carboxamide (5), characterised in that the ring opening is carried out under conditions of elevated pressure.
L'invention concerne un procédé de préparation de 10,11-dihydro-10-hydroxy-5H-dibenzo/b,f/azépine-5-carboxamide (1) par ouverture de cycle de 11a,10b-dihydro-6H-dibenzo/b,f/oxiréno[d]azépine-6-carboxamide (5), caractérisé en ce que l'ouverture de cycle est effectuée dans des conditions de pression élevée.
Kraemer Matthias
Learmonth David Alexander
Weingaertner Guenter
Bial - Portela & C.a. S.a.
Portela & C.a. S.a.
Sim & Mcburney
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