C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/22 (2006.01) A61K 31/55 (2006.01) A61P 25/08 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2448094
A method for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine- 5-carboxamide and 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide from carbamazepine via a three-step process involving (i) epoxidation of carbamazepine; (ii) ring-opening of the resulting epoxide and (iii) oxidation of the resulting alcohol.
Procédé de préparation de 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azépine-5-carboxamide et de 10,11-dihydro-10-oxo-5H-dibenz/b,f/azépine-5-carboxamide à partir de carbamazépine par l'intermédiaire d'un procédé en trois étapes comprenant (i) une époxydation de carbamazépine; (ii) une ouverture du noyau de l'époxyde obtenu (iii) une oxydation de l'alcool obtenu.
Bial - Portela & C.a. S.a.
Portela & Ca Sa
Sim & Mcburney
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