A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01)
Patent
CA 2516448
Melt agglomeration for the preparation of an agglomerated material is performed us-ing a vehicle that can be melted at a suitable temperature, an active compound and silicon dioxide as filler. Using silicon dioxide as a filler in melt agglomeration has the benefit that a high ratio of melt to filler may be used. Agglomerates prepared by the process proved to be readily compressible into tablets using common equipment.Melt agglomeration for the preparation of an agglomerated material is performed us-ing a vehicle that can be melted at a suitable temperature, an active compound and silicon dioxide as filler. Using silicon dioxide as a filler in melt agglomeration has the benefit that a high ratio of melt to filler may be used. Agglomerates prepared by the process proved to be readily compressible into tablets using common equipment.
L'invention concerne un procédé d'agglomération à chaud destiné à la préparation d'un aggloméré, faisant intervenir un adjuvant pouvant être fondu à une température adaptée, un composé actif et de la silice comme charge. L'utilisation de la silice comme charge dans l'agglomération à chaud permet d'obtenir un rapport de matière fondue par rapport à la charge élevé. Les agglomérés préparés selon ce procédé peuvent être facilement transformés en comprimés à l'aide d'un équipement conventionnel.
Goudreau Gage Dubuc
H. Lundbeck A/s
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