Method for preparation of n-phosphonomethylglycine

Details Method for preparation of n-phosphonomethylglycine Method for preparation of n-phosphonomethylglycine

C - Chemistry, Metallurgy

07

F

260/501.5

C07F 9/38 (2006.01) C07D 233/78 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 1205817

METHOD FOR PREPARATION OF N-PHOSPHONOMETHYLGLYCINE Abstract of the Invention Disclosed is a method for the preparation of N-phosphonomethyl- glycine which comprises the steps of (a) reacting hydantoin or a 3-sub- stituted hydantoin, a compound of the formula Image wherein R is selected from the group consisting of hydrogen, alkyl having from 1 to 10 carbon atoms, aryl having from 6 to 12 carbon atoms, alkyl- carbonyl wherein the alkyl group has from 1 to 10 carbon atoms, and aryl- carbonyl wherein the aryl group has from 6 to 12 carbon atoms, with para- formaldehyde in the presence of a low molecular weight carboxylic acid at a temperature and for a sufficient period of time to produce a mixture of intermediate products, including the 1-hydroxymethyl derivative of the starting hydantion (b) converting said 1-hydroxymethyl derivative to the 1-phosphonomethyl derivative by thereafter adding to the reaction mixture either (i) a substituted phosphorus compound selected from the group con- sisting of phosphorus trichloride, and phosphorus tribromide; or (ii) adding to the reaction mixture phosphorous acid and a anhydride selected from the group consisting acetic anhydride, propionic anhydride, butyric anhydride, or mixture thereof, and continuing said reaction at a tenpera- ture and for a sufficient period of time to cause completion of the reac- tion to form the 1-phosphonomethyl derivative; and (c) hydrolyzing the 1-phosphonomethylhydantoin product thus formed with a base selected from the group consisting of alkali metal or alkaline earth hydroxide, to pro- duce a salt of N-phosphonomethylglycine; and (d) neutralizing said salt with a strong acid to produce the end product, N-phosphonomethylglycine.

439087

Affiliated with

Also associated with

Rating

Method for preparation of n-phosphonomethylglycine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for preparation of n-phosphonomethylglycine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparation of n-phosphonomethylglycine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1228142