C - Chemistry – Metallurgy – 08 – J
Patent
C - Chemistry, Metallurgy
08
J
C08J 3/12 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) C08J 3/00 (2006.01)
Patent
CA 2303179
The present invention relates to a new method for the production of polymer microparticles. The method is carried out in the absence of organic solvent, and consists in the steps of (a) combining first and second polymers, the first and second polymers being incompatible or immiscible, (b) heating the combination obtained in step (a) so as to melt the first and second polymers; (c) shaking the melted polymers obtained in step (b) under conditions effective to produce a biphasic system, the biphasic system comprising a dispersed phase and a matrix continuous phase, the dispersed phase consisting of a dispersion of the first polymer, the matrix continuous phase comprising the second polymer, the dispersed phase containing microparticles of the first polymer dispersed in the matrix continuous phase; (d) solidifying the biphasic system obtained in step (c) so as to keep the microparticles of the first polymer dispersed in the matrix continuous phase; and (e) separating and isolating the microparticles of the first polymer from the matrix continuous phase, wherein the first polymer in said dispersed phase is water-insoluble, while the second polymer forming the continuous phase is water-soluble.
La présente invention concerne un nouveau procédé de production de microparticules polymères. Le procédé est mis en oeuvre en l'absence de solvant organique et consiste (a): à combiner un premier et un second polymères, les premier et second polymères étant incompatibles ou non miscibles; (b) à réchauffer la combinaison obtenue sous (a) de manière à fondre le premier et le second polymère; (c) à secouer les polymères fondus obtenus sous (b) dans des conditions permettant d'obtenir un système biphasé, ledit système biphasé comprenant une phase dispersée et une phase matricielle continue, la phase dispersée étant composée d'une dispersion du premier polymère, la phase matricielle continue comprenant le second polymère, et la phase dispersée comprenant des microparticules du premier polymère dispersées dans la phase matricielle continue; (d) à solidifier le système biphasé obtenu sous (c) afin de maintenir les microparticules du premier polymère dispersées dans la phase matricielle continue; et (e) à séparer et isoler les microparticules du premier polymère de la phase matricielle continue, le premier polymère de ladite phase dispersée étant non soluble dans l'eau et le second polymère formant la phase continue étant soluble dans l'eau.
Chaput Cyril
Chenite Abdellatif
Selmani Amine
Bio Syntech Canada Inc.
Bio Syntech Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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