Method for preparing 2-pyrazolin-5-ones from 1,2,4- oxadiazoles

Details Method for preparing 2-pyrazolin-5-ones from 1,2,4- oxadiazoles Method for preparing 2-pyrazolin-5-ones from 1,2,4- oxadiazoles

C - Chemistry, Metallurgy

07

D

260/315.4, 260/3

C07D 413/12 (2006.01) C07D 231/52 (2006.01)

Patent

CA 1167456

Abstract of the Disclosure A method for preparing 2-pyrazolin-5-ones from 1,2,4-oxadiazoles is described. The method comprises forming a substantially nonaqueous liquid reaction system of a base catalyst and a 1,2,4-oxadiazole in an organic liquid reaction medium and heating the reaction system to a temperature sufficient to cause the 1,2,4-oxadiazole to be arranged to a 2-pyrazolin-5-one. The 1,2,4-oxadiazoles to be treated by the method of this invention are represented by the structural formula: Image wherein each of R1, R2 and R3 is hydrogen, halo, alkyl having from 1 to 5 carbon atoms, or alkoxy having from 1 to 5 carbon atoms; and J is alkyl having from 1 to 20 carbon atoms, phenoxyalkyl with the alkyl portion thereof having from 1 to 20 carbon atoms, phenyl, alkoxyphenyl, furyl, phenoxyacylaminophenyl, or phenoxyalkyl substituted with one or more nitro radicals in at least one of the para or ortho positions.

389917

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