Method for preparing 3'-aminopropyl-2-sulphatoethylsulphone

Details Method for preparing 3'-aminopropyl-2-sulphatoethylsulphone Method for preparing 3'-aminopropyl-2-sulphatoethylsulphone

C - Chemistry, Metallurgy

07

C

C07C 317/28 (2006.01) C07C 315/02 (2006.01)

Patent

CA 2104945

HOE 91/F 063 ~ 12 - Abstract of the disclosure Process for the preparation of 3'-aminopropyl 2-sulfato- ethyl sulfone Process for the preparation of 3'-aminopropyl 2-sulfato- ethyl sulfone in high yield, which comprises reacting allylamine with mercaptoethanol in aqueous sulfuric acid in a one-pot process at temperatures from about 25°C to the boiling point of the reaction mixture in the presence of free-radical initiators which are soluble in the reaction medium, oxidizing the reaction mixture thus obtained with hydrogen peroxide in the presence of catalytic amounts of a compound of a transition metal of the periodic table of elements as oxidation catalyst to give 3'-aminopropyl 2-hydroxyethyl sulfone hemisulfate, adding further sulfuric acid until the total amount of sulfuric acid in the mixture is at least 1 mol, relative to the allylamine used, and esterifying the 3'-amino- propyl 2-hydroxyethyl sulfone hem.isulfate obtained after oxidation by evaporation to dryness or with sulfuric acid or oleum or chlorosulfonic acid in solution.

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