Method for preparing a composition

A - Human Necessities – 61 – K

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A61K 9/20 (2006.01) A61K 9/16 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2411153

The present invention relates to a method for the preparation of compositions, preferably pharmaceutical compositions, in form of expanded, mechanically stable, lamellar, porous, spongue-like or foam structures out of solutions and dispersions. This method comprises the steps of a) preparing a solution or a homogeneous dispersion of a liquid and a compound selected from the group consisting of one or more pharmaceutically active compounds, one or more pharmaceutically suitable excipients, and mixtures thereof, followed by b) the expansion of the solution or the homogeneous dispersion without boiling. The invention also relates to the compositions, their further processing and any corresponding dosage forms obtainable by the above method.

Cette invention porte sur un procédé de préparation de compositions, de préférence des compositions pharmaceutiques, sous forme de structures de type spongieux ou en mousse expansées, mécaniquement stables, lamellaires, poreuses, tirées de solutions et de dispersions. Ce procédé comprend les étapes suivantes : a) préparation d'une solution ou d'une dispersion homogène d'un liquide et d'un composé sélectionné dans le groupe formé par un ou plusieurs composés pharmaceutiquement actifs, un ou plusieurs excipients pharmaceutiquement appropriés et des mélanges de ceux-ci, suivie de b) l'expansion de la solution ou de la dispersion homogène sans porter à ébullition. L'invention porte également sur les compositions, leur traitement ultérieur et toutes les formes galéniques correspondantes obtenues à partir dudit procédé.

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