Method for preparing a composition containing at least an...

C - Chemistry – Metallurgy – 07 – B

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C07B 63/04 (2006.01) A61K 31/045 (2006.01) A61K 31/047 (2006.01) A61K 31/336 (2006.01) A61K 31/34 (2006.01) C07D 307/20 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2466935

The invention concerns a novel method for preparing a composition for internal dehydration of a hydrogenated sugar, characterized in that it comprises: a) a step which consists in distillation of a medium containing said internal dehydration product to obtain a distillate enriched with said product; b) optionally at least a subsequent step which consists in purifying the resulting distillate; c) a subsequent step which consists in bringing said distillate obtained at step a), optionally subjected to step b), in the presence of an agent capable of enhancing the stability of the internal dehydration product contained for the major part in the distillate, said agent not being in gaseous form; d) optionally a subsequent step which consists in forming the resulting composition for internal dehydration of a hydrogenated sugar. Said method enables in particular to obtain a stable isosorbide composition, characterized by its purity and/or its content of certain species, whether stabilizing or not.

La présente invention a pour objet un nouveau procédé de préparation d'une composition de produit de déshydratation interne d'un sucre hydrogéné, caractérisé par le fait qu'il comprend a) une étape de distillation d'un milieu contenant dudit produit de déshydratation interne en vue d'obtenir un distillat enrichi en ce produit, b) éventuellement, au moins une étape subséquente de purification du distillat ainsi obtenu, c) une étape subséquente de mise en présence du distillat obtenu lors de l'étape a) puis éventuellement soumis à l'étape b), avec un agent apte à améliorer la stabilité du produit de déshydratation interne majoritairement contenu dans le distillat, ledit agent n'étant pas sous forme gazeuse, d) éventuellement, une étape subséquente de mise en forme de la composition résultante de produit de déshydratation interne d'un sucre hydrogéné. Ce procédé permet notamment d'obtenir une composition d'isosorbide stable, caractérisée par sa pureté et/ou sa teneur en certaines espèces, stabilisantes ou non.

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