C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/70 (2006.01) A61K 31/44 (2006.01) C07C 17/16 (2006.01)
Patent
CA 2275592
The invention relates to a method for the preparation of 1-[2-(2- naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine and its pharmaceutically acceptable salts by reacting 2-(2-bromoethyl)naphthalene with 4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine or one of its salts, and to a universal method for the preparation of the same product and its salts by the reduction of naphthylacetic acid, treatment of the resulting 2-naphthylethanol with hydrobromic acid and treatment of the 2-(2-bromoethyl)naphthalene with 4-(3- trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine or one of its salts.
L'invention concerne un procédé pour la préparation de la 1-[2-(2-naphtyl)éthyl]-4-(3-trifluorométhylphényl)-1,2,3,6-tétrahydropyridine de formule (I) et de ses sels pharmaceutiquement acceptables par réaction du 2-(2-bromoéthyl)naphtalène avec la 4-(3-trifluorométhylphényl)-1,2,3,6-tétrahydropyridine ou un de ses sels, et un procédé global pour la préparation du même produit et de ses sels par réduction de l'acide naphtylacétique, traitement du 2-naphtyléthanol ainsi obtenu avec de l'acide bromhydrique et traitement du 2-(2-bromoéthyl)naphtalène avec la 4-(3-trifluorométhylphényl)-1,2,3,6-tétrahydropyridine ou un de ses sels.
Buj Michel
Filhol Robert
Sanofi
Sanofi-Aventis
Sim & Mcburney
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