Method for preparing alpha-sulfonyl hydroxamic acid derivatives

Details Method for preparing alpha-sulfonyl hydroxamic acid derivatives Method for preparing alpha-sulfonyl hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 211/60 (2006.01) A61K 31/4462 (2006.01) A61K 31/4465 (2006.01) C07D 211/66 (2006.01)

Patent

CA 2398561

Compounds of the formula (I) that can be important as matrix metalloproteinase (MMP) and TNF-alpha converting enzyme (TACE) inhibitors, phosphodiesterase inhibitors, renin inhibitors, antithrombotics, and 5-lipoxygenase inhibitors are prepared by novel methods of the present invention.

Cette invention se rapporte à des composés représentés par la formule (I), qui peuvent jouer un rôle important comme inhibiteurs de la métalloprotéinase matricielle (MMP) et de l'enzyme de conversion du facteur de nécrose tumorale (TNF) alpha (TACE), comme inhibiteurs de la phosphodiestérase, comme inhibiteurs de la rénine, comme agents antithrombotiques et comme inhibiteurs de la 5-lipoxygénase. Ces composés sont préparés par de nouveaux procédés faisant l'objet de cette invention.

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