Method for preparing an antihypertensive agent comprising...

Details Method for preparing an antihypertensive agent comprising... Method for preparing an antihypertensive agent comprising...

C - Chemistry, Metallurgy

07

F

260/460.6

C07F 9/10 (2006.01)

Patent

CA 1169433

METHOD FOR PREPARING AN ANTIHYPERTENSIVE AGENT COMPRISING 1-0-ALKYL-2-ACETOYL-SN-GLYCERO-3-PHOSPHOCHOLINE ABSTRACT OF THE DISCLOSURE The composition of this invention is I-O-alkyl-2-acetoyl-sn- glycero-3-phosphocholine, having the ionic structural formula: Image wherein R is saturated alkyl having 9-21 carbon atoms, or salts or hydrates of the composition. Preferably R has 13-19 carbon atoms and most preferably R has 15 carbon atoms. The composition of this inven- tion is useful for reducing hypertension in warm-blooded animals, including humans, when administered either orally or by injection or innoculation, e.g., intravenous injection. The composition can be prepared from naturally occurring lipids or synthetically from commer- cially available material. The invention includes the method of preparing the composition and the composition itself when prepared by that method.

363099

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