C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/08 (2006.01) C07C 303/08 (2006.01)
Patent
CA 2462297
The present disclosure provides a method for the preparation of aromatic sulfonyl halides by contacting a substituted phenyl compound with a halosulfonic acid and trifluoroacetic acid. The present disclosure further provides a method for the preparation of a 4-[5-methyl-3- phenylisoxazol-4-yl]benzenesulfonamide of the formula: (See formula I) which is useful in treating cyclooxygenase-2 related disorders.
L'invention concerne un procédé de préparation d'halogénures sulfonyl aromatiques consistant à mettre en contact un composé de phényle substitué avec un acide halosulfonique et un acide trifluoroacétique. Par ailleurs, l'invention concerne un procédé de préparation de 4-[5-méthyl-3-phénylisoxazol-4-yl]benzènesulfonamide utilisé dans le traitement les maladies liées à la cyclooxygénase-2.
Gallagher Donald J.
Kunda Sastry A.
Letendre Leo J.
Mclaughlin Kathleen
Seaney Lisa M.
Pharmacia Corporation
Smart & Biggar
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