Method for preparing benzo¬.alpha.|phenazine derivatives

Details Method for preparing benzo¬.alpha.|phenazine derivatives Method for preparing benzo¬.alpha.|phenazine derivatives

C - Chemistry, Metallurgy

07

D

167/224, 260/265

C07D 241/46 (2006.01) C07D 241/38 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01)

Patent

CA 1248106

ABSTRACT Novel benzo[a]phenazine derivatives of the formula Image (I) wherein R1 is hydrogen, halogen, methyl, hydroxyl or alkoxy, R2 is -COOR5 (wherein R5 is hydrogen, straight or branched chain alkyl, cycloalkyl having 3 - 6 carbon atoms, benzyl or phenyl) or -CON Image (wherein R6 and R7 are the same or different and are each hydrogen or lower alkyl, or R6 and R7 together with the nitrogen atom to which they are attached form pyrrolidine or piperidine), R3 and R4 are the same or different and are each hydrogen or lower alkyl, and n is an integer of 2 or 3, and the salts thereof are disclosed. These compounds have antitumor activity in mammals.

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