C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/254, 260/471
C07C 327/04 (2006.01) A61K 31/10 (2006.01) A61K 31/185 (2006.01) A61K 31/265 (2006.01)
Patent
CA 1240696
ABSTRACT A method for preparing a benzoylpropionic acid derivative represented by the general formula Image (I) (wherein R1 represents a hydrogen atom, a lower alkyl group or a benzyl group, R2 represents a lower alkyl group or a phenyl group, x represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a phenoxy group or a halogenophenoxy group, and Y repre- sents a hydrogen atom or a lower alkyl group) which comprises reacting a carboxylic acid compound repre- sented by the general formula Image (II) (wherein X and Y are as defined above) with a thiocar- boxylic acid represented by the general formula R2COSH (wherein R2 is as defined above) in the presence of a basic catalyst in an organic solvent and, if desired, further reacting the resulting product with an alky- lating agent having R1 other than a hydrogen atom in the presence of a base in an organic solvent. These compounds have an immunomodulative function and are effective for treatment of diseases caused by abnormal immunofunction.
483104
Kameo Kazuya
Matsunaga Toru
Saito Shiuji
Sota Kaoru
Tomisawa Kazuyuki
Fetherstonhaugh & Co.
Taisho Pharmaceutical Co. Ltd.
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