Method for preparing crystal of aspartame derivative...

C - Chemistry – Metallurgy – 07 – K

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C07K 5/075 (2006.01)

Patent

CA 2348162

A method for preparing the A type crystal of N-(3,3-dimethylbutyl)-APM being excellent in stability, which comprises holding the B type crystal thereof under a controlled circumstance of an absolute humidity of 0.203 kg/kg or lower and a material temperature of 25 to 80 ~C, to thereby cause crystal transition; and a method for preparing the A type crystal of N-(3,3- dimethylbutyl)-APM comprising holding the D type crystal thereof under a controlled circumstance of an absolute humidity of 0.0550 kg/kg or lower and a material temperature of 25 to 80 ~C, to thereby cause crystal transition. These crystal transition methods allow the preparation of a crystal excellent in stability with a low cost and with stability.

Procédé de préparation du cristal de type A de N-(3,3-diméthylbutyl)-APM qui possède une excellente stabilité. Ledit procédé consiste à maintenir le cristal de type B de ladite substance dans des conditions régulées d'humidité absolue de 0,203 kg/kg ou moins et de température de la matière entre 25 et 80 ·C, ce qui provoque la transition du cristal. La présente invention concerne également un procédé de préparation du cristal de type A de N-(3,3-diméthylbutyl)-APM qui consiste à maintenir le cristal de type D de ladite substance dans des conditions régulées d'humidité absolue de 0,0550 kg/kg ou moins et de température de la matière entre 25 et 80 ·C, ce qui provoque la transition du cristal. Ces procédés de transition du cristal permettent la préparation d'un cristal d'une excellente stabilité à un coût peu élevé.

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