Method for preparing cyanophosphonate derivatives from...

Details Method for preparing cyanophosphonate derivatives from... Method for preparing cyanophosphonate derivatives from...

A - Human Necessities

61

K

A61K 31/00 (2006.01) C07F 9/38 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2276158

A process for preparing cyanophosphonate derivatives involves contacting phosphoric anhydride (P4O10) and a cyanide, preferably in the presence of a Lewis base, in a reaction mixture under sufficient conditions to produce a cyanophosphonate derivative. The cyanophosphonate derivative can be subsequently hydrogenated to produce an aminomethylphosphonate derivative.

Cette invention se rapporte à un procédé de préparation de dérivés cyanophosphonates qui consiste à mettre en contact de l'anhydride phosphorique (P¿4?O¿10?) et un cyanure, de préférence en présence d'une base de Lewis, au sein d'un mélange réactionnel, dans des conditions favorisant la production d'un dérivé cyanophosphonate. Il est ensuite possible d'hydrogéner ledit dérivé cyanophosphonate de manière à obtenir un dérivé aminométhylphosphonate.

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