Method for preparing [f-18]-fluoride ion

Details Method for preparing [f-18]-fluoride ion Method for preparing [f-18]-fluoride ion

B - Operations, Transporting

01

D

B01D 59/30 (2006.01) C07B 59/00 (2006.01) G21G 1/10 (2006.01)

Patent

CA 2265426

The present invention provides a method for preparing [F-18]-fluoride ion which comprises the step of bringing [O-18]-enriched water containing [F-18]- fluoride ion formed by proton irradiation of [O-18]- enriched water into contact with a strongly acidic cation exchange resin to remove impurity cations, the step of then bringing the [O-18]-enriched water contain- ing [F-18]-fluoride ion treated above into contact with a weakly basic anion exchange resin to make [F-18]- fluoride ion adsorbed to the resin and, along therewith, to recover the [O-18]-enriched water which has passed through the resin, and the step of eluting and collecting the [F-18]-fluoride ion adsorbed to the weakly basic anion exchange resin. According to the method for preparing [F-18]-fluoride ion of the present invention, [F-18]-fluoride ion can be collected at a high collection efficiency even from a larger amount (about 2 ml or more) of [O-18]-enriched water containing [F-18]-fluoride ion than the amount in prior method, and moreover expensive [O-18]-enriched water can be recovered and reused in the preparation of [F-18]- fluoride ion.

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