Method for preparing fmoc - based hydrolysable linkers

Details Method for preparing fmoc - based hydrolysable linkers Method for preparing fmoc - based hydrolysable linkers

C - Chemistry, Metallurgy

07

D

C07D 207/448 (2006.01)

Patent

CA 2690553

A novel process for the production of Fmoc (9H-fluoren-9-ylmethoxycarbonyl)- based compounds is provided, wherein a protecting group for the 9-hydroxymethyl group of the fluorene ring system is utilized. These compounds are useful for the modification of protein and peptide drugs.

L'invention concerne un nouveau procédé de production de composés à base de Fmoc (9H-fluorèn-9-ylméthoxycarbonyle), un groupe protecteur pour le groupe 9-hydroxyméthyle du système cyclique fluorène étant utilisé. Ces composés sont utiles pour la modification de médicaments protéiques et peptidiques.

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