Method for preparing homochiral maleimide intermediates, via...

Details Method for preparing homochiral maleimide intermediates, via... Method for preparing homochiral maleimide intermediates, via...

C - Chemistry, Metallurgy

07

D

C07D 207/448 (2006.01) C07D 207/452 (2006.01) C07D 491/18 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2146038

A method is provided for preparing homochiral maleimide intermediates of the structure Image wherein R7, R8 and R9 are as defined herein by reacting a homochiral amine of the structure Image with maleic anhydride and a silylating agent. The maleimide intermediate is used in the enantio- selective preparation of thromboxane A2 receptor antagonists.

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