Method for preparing human immunoglobulin concentrates for...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/06 (2006.01) C07K 1/18 (2006.01) C07K 1/30 (2006.01) C07K 1/36 (2006.01)

Patent

CA 2446704

The invention concerns a method for preparing human immunoglobulin concentrates for therapeutic use, from plasma or a plasma fraction. The method comprises pre-purification and a single anion-exchange chromatography carried out at alkaline pH, thereby enabling the immunoglobulins to be retained on the chromatographic support and fractionated. The method enables to obtain IgG, IgA and IgM concentrates.

L'invention concerne un procédé de préparation de concentrés d'immunoglobulines humaines à usage thérapeutique, à partir de plasma ou d'une fraction de plasma. Le procédé comprend une prépurification et une chromatographie unique sur échangeur d'anions effectuée à pH alcalin, ce qui permet la rétention des immunoglobulines sur le support chromatographique et leur fractionnement. Le procédé permet d'obtenir des concentrés d'immunoglobulines G, A et M.

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