Method for preparing immunoglobulin libraries

Details Method for preparing immunoglobulin libraries Method for preparing immunoglobulin libraries

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/42 (2006.01) C07K 16/10 (2006.01) C40B 40/02 (2006.01)

Patent

CA 2622603

The invention relates to methods of construction of human immunoglobulin libraries, by isolating B memory cells (IgM memory, class-switched or plasma blast cells) . The libraries are generated on the surface of replicable genetic packages, such as phages. It also relates to methods of screening said libraries and the immunoglobulins identified in said screenings. Additionally, the invention relates to human binding molecules that bind to H5N1 virus, in particular antibodies and immunoconjugates. Pharmaceutical compositions comprising said binding molecules are also disclosed.

L'invention concerne la génération de bibliothèques d'immunoglobuline et l'identification et la production d'immunoglobulines présentant une fonctionnalité d'intérêt spécifique.

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