A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
3/141, 167/156,
A61L 2/18 (2006.01) A61L 17/00 (2006.01) A61L 27/00 (2006.01) A61L 27/54 (2006.01) A61L 29/00 (2006.01) A61L 29/16 (2006.01)
Patent
CA 1268118
ABSTRACT OF THE DISCLOSURE An infection-resistant polymeric material, such as polytetrafluoroethylene, for use on or within a human or animal body, for example, in the form of a vascular graft, can be prepared by an improved method which comprises the following sequence of steps: (a) soaking a polymeric material with a solution of an antimicrobial agent, such as sodium sulfadiazine, oxacillin dissolved in an organic solvent therefor, such as an ethanol/chloroform mixture; (b) soaking the polymeric material with an organic solvent, such as ethanol, for a metal salt; and (c) resoaking the polymeric material with the solution of the antimicrobial agent dissolved in the organic solvent therefor. The polymeric material is dried after each soaking step. Preferably, in the intermediate soaking step (b) the organic solvent contains a metal salt, such as silver nitrate, dissolved therein, so as to form in situ the metal salt of the antimicrobial agent, such as silver sulfadiazine.
510507
Fox Charles Lewis Jr.
Modak Shanta M.
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University
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