Method for preparing -l-aspartyl-l-phenylalanine methyl ester

Details Method for preparing -l-aspartyl-l-phenylalanine methyl ester Method for preparing -l-aspartyl-l-phenylalanine methyl ester

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/075 (2006.01)

Patent

CA 2018896

- 25 - ABSTRACT OF THE DISCLOSURE A method for preparing .alpha.-L-aspartyl-L- phenylalanine methyl ester (.alpha.-APM), substantially free from acid ion contamination, is disclosed which comprises the steps of contacting a solution of a mineral acid salt or an organic sulfonic acid salt of .alpha.-APM in an aqueous solvent with an anion exchange resin in free base form, separating the resin from the thus-produced solution of .alpha.-APM; and isolating the .alpha.-APM therefrom, preferably with regeneration and recycling the resin.

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