A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) A61K 9/107 (2006.01) A61K 31/192 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2690479
The present invention relates to a method for use in the preparation of nanocapsules which have a liquid lipid core and a solid lipid shell and which are loaded with at least one active agent, wherein said method comprises at least the steps consisting in providing a microemulsion formulated by phase inversion of an emulsion, providing a second composition, distinct from said microemulsion and completely or partly formed from at least one active agent, placing said microemulsion in the presence of said second composition under conditions suitable for the interaction of said active agent with said microemulsion and annealing said microemulsion having interacted with said active agent in such a way as to obtain said nanocapsules. The invention also relates to a corresponding kit.
La présente invention concerne un procédé utile pour la préparation de nanocapsules à coeur lipidique liquide, écorce lipidique solide et chargées en au moins un actif, ledit procédé comprenant au moins les étapes consistant à disposer d'une microé-mulsion formulée par inversion de phase d'une émulsion, disposer d'une seconde composition, distincte de ladite microémulsion et formée en tout ou partie d'au moins un actif, mettre en présence ladite microémulsion avec ladite seconde composition dans des conditions propices à l'interaction dudit actif avec ladite microémulsion et effectuer la trempe de ladite microémulsion ayant interagi avec ledit actif de manière à obtenir lesdites nanocapsules. L'invention vise en outre un kit correspondant.
Anton Nicolas
Benoit Jean-Pierre
Saulnier Patrick
Robic
Universite D'angers
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