B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
B01J 13/04 (2006.01)
Patent
CA 2746706
The present invention relates to a useful method for preparing nanocapsules with a liquid lipid core and a hard shell and loaded with at least one hydrophilic active agent, said method including at least the steps of: i) using at least one first water-in-oil microemulsion containing, in the hydrophilic phase thereof, at least one hydrophilic active agent; ii) using at least one second microemulsion that is formulated by the phase inversion of an emulsion; iii) adding said first microemulsion into said second microemulsion under conditions that are conducive to the formation of a novel microemulsion architecture wherein said hydrophilic active agent remains present in the hydrophilic phase of the first microemulsion; and iv) quenching the mixture that is formed in the preceding step so as to obtain microcapsules containing said hydrophilic active agent and being made of a lipid core that is liquid at room temperature and coated in a hard film at room temperature. The invention also relates to nanocapsules obtainable by said method.
La présente invention concerne un procédé utile pour la préparation de nanocapsules à coeur lipidique liquide, écorce solide et chargées en au moins un actif à caractère hydrophile, ledit procédé comprenant au moins les étapes consistant à: i) disposer d'au moins une première microémulsion à caractère eau-dans-huile contenant au niveau de sa phase hydrophile au moins un actif à caractère hydrophile, ii) disposer d'au moins une seconde microémulsion, formulée par inversion de phase d'une émulsion, iii) ajouter ladite première microémulsion dans ladite seconde microémulsion, dans des conditions propices à la formation d'une nouvelle architecture microémulsion dans laquelle ledit actif hydrophile demeure présent au niveau de la phase hydrophile de la première microémulsion, et iv) effectuer la trempe du mélange formé à l'étape précédente, de manière à obtenir des nanocapsules comprenant ledit actif hydrophile et étant formées d'un coeur lipidique, liquide à température ambiante et enrobé d'un film solide à température ambiante. L'invention vise en outre des nanocapsules susceptibles d'être obtenues par ce procédé.
Benoit Jean-Pierre
Ramadan Alyaa Adel
Saulnier Patrick
Thomas Olivier
Institut National de La Sante Et de La Recherche Medicale (inser
Robic
Universite D'angers
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