Method for preparing low dose pharmaceutical products

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/56 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01)

Patent

CA 2176461

Disclosed is a wet method for preparing solid pharmaceutical composition for oral administration of low-dose medications whose active ingredients have steroidal or steroid-like structures. The method suspends medicaments with low solubility in an aqueous binder solution with a trace amount of amount. The aqueous suspension is then blended with fillers and granulated. The dried granules can be made into capsules, tablets, lozenges, troches, sustained or delayed release products or suspensions.

Procédé par voie humide utilisé pour préparer une composition pharmaceutique solide destinée à l'administration par voie orale de médicaments à faible dosage dont les principes actifs présentent des structures stéroïdiennes ou de type stéroïdien. Ce procédé consiste à mettre en suspension des médicaments ayant une faible solubilité, dans une solution aqueuse de liant contenant des traces d'un tensioactif. On mélange ensuite cette suspension aqueuse à des charges de remplissage et on les met sous forme de granules. Les granules déshydratés peuvent être ensuite transformés en capsules, comprimés, pastilles, tablettes, produits ou suspensions à libération prolongée ou retardée.

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