A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) C08F 22/14 (2006.01) C08F 22/20 (2006.01)
Patent
CA 2269783
The invention concerns a method for preparing nanoparticles formed of a statistic polymer of at least one compound of formula (I) in which A represents a group (a) or a group (b); R1 and R2, identical or different, represent a C1-C6 alkyl group linear or branched; n = 1, 2, 3, 4, or 5, characterised in that the monomer is previously made soluble in an organic aprotic solvent miscible in water forming with the polymerisation medium a mixture non-solvent of the formed polymer. The invention also concerns said nanoparticles, containing optionally one or several biologically active molecules, and the pharmaceutical compositions containing them.
L'invention concerne un procédé de préparation de nanoparticules formées d'un polymère statistique d'au moins un composé de formule (I) dans laquelle A représente un groupe (a) ou un groupe (b), R1 et R2, identiques ou différents, représentent un groupe C1-C6 alkyle linéaire ou ramifié; n = 1, 2, 3, 4 ou 5, caractérisé en ce que le monomère est préalablement solubilisé dans un solvant organique aprotique miscible à l'eau formant avec le milieu de polymérisation un mélange non solvant du polymère formé. L'invention concerne également lesdites nanoparticules, contenant éventuellement une ou plusieurs molécules biologiquement actives, et les compositions pharmaceutiques les contenant.
Breton Pascal
Bru-Magniez Nicole
Couvreur Patrick
Guillon Xavier
Lescure Francois
Sim & Mcburney
Virsol
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