Method for preparing n-¬4-¬¬(2,4-diamino-6- pteridinyl)-...

Details Method for preparing n-¬4-¬¬(2,4-diamino-6- pteridinyl)-... Method for preparing n-¬4-¬¬(2,4-diamino-6- pteridinyl)-...

C - Chemistry, Metallurgy

07

D

260/242.1, 260/2

C07D 475/06 (2006.01) C07D 241/26 (2006.01) C07D 475/04 (2006.01) C07D 475/08 (2006.01)

Patent

CA 1179338

ABSTRACT OF THE DISCLOSURE Methotrexate, N-[4-[[(2,4-diamino-6- pteridinyl)-methyl]methylamino]benzoyl]glutamic acid, useful in treatment of cancerous diseases, is prepared by reacting N-[4-[[(2-Amino-3-cyano-5-pyrazinyl) methyl]methylamino]benzoyl]glutamic acid with guanidine or a guanidine salt of a weak inorganic or organic acid.

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