Method for preparing pertussis toxin toxoid

Details Method for preparing pertussis toxin toxoid Method for preparing pertussis toxin toxoid

C - Chemistry, Metallurgy

07

K

530/15.04

C07K 14/235 (2006.01) A61K 39/10 (2006.01)

Patent

CA 2004206

Disclosed is a method for preparing pertussis toxin toxoid by a treatment of pertussis toxin with formaldehyde, which comprises carrying out said treatment in the presence of lysine or glycine in combination with N-acetyltryptophan. The resultant toxoid does not exhibit toxicity reversion, thereby making the toxoid highly suitable for use in pertussis vaccines.

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