Method for preparing pharmaceutical formulations

Details Method for preparing pharmaceutical formulations Method for preparing pharmaceutical formulations

A - Human Necessities

61

K

A61K 31/522 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61P 31/12 (2006.01) A61P 31/22 (2006.01)

Patent

CA 2301325

A pharmaceutical formulation may be prepared by a method comprising providing the active ingredient in solution in a pharmacologically-acceptable base and mixing the resulting solution with a pharmacologically-acceptable acid in an amount such that the formulation attains a pH in the range of from about 3.5 to about 8.5 to thereby precipitate out the active ingredients, a viscosity- enhancing agent having been incorporated in the formulation prior to or during the mixing with acid. The formulation is suitable for administration of a pharmacologically active ingredient which is sparingly soluble in water at a pH acceptable for administration, for example to the eye of the patient.

Selon cette invention, une composition pharmaceutique peut être préparée grâce à un procédé consistant à mettre le principe actif en solution dans une base pharmacologiquement acceptable et à mélanger la solution résultante avec un acide pharmacologiquement acceptable dont la quantité est telle que le pH de la composition atteint des valeurs comprises entre environ 3,5 et 8,5. Le précipité des principes actifs est ainsi obtenu. Un agent d'accentuation de la viscosité a été introduit dans la composition avant ou pendant le mélange avec l'acide. Cette composition convient à l'administration d'un principe actif du point de vue pharmacologique et modérément soluble dans de l'eau dont le pH est acceptable pour une administration à l'oeil d'un patient par exemple.

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