Method for preparing polymer micelle pharmaceutical...

A - Human Necessities – 61 – K

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A61K 9/107 (2006.01) A61K 9/19 (2006.01) A61K 31/337 (2006.01) A61K 31/407 (2006.01) A61K 31/4745 (2006.01) A61K 31/519 (2006.01) A61K 31/557 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2487117

A method for preparing a pharmaceutical preparation containing polymer micelles having a drug included therein, which comprises the steps of dissolving a hydrophilic-hydrophobic block copolymer and a drug being sparingly soluble in water in a volatile organic solvent, removing the solvent, and agitating the resultant residue together with water at a temperature of 30~C or lower, to homogeneously disperse the resultant polymer micelles into water.

Cette invention a trait à un procédé de production d'une préparation pharmaceutique contenant des micelles polymère renfermant un médicament. Ce procédé consiste à dissoudre un copolymère séquencé hydrophile hydrophobe ainsi qu'un médicament peu soluble dans l'eau dans un solvant organique volatil, à enlever le solvant et à agiter le produit résultant avec de l'eau à une température égale ou inférieure à 30·C, afin de disperser uniformément les micelles dans l'eau.

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