Method for preparing prostaglandin derivative

Details Method for preparing prostaglandin derivative Method for preparing prostaglandin derivative

C - Chemistry, Metallurgy

07

D

C07D 307/93 (2006.01) C07C 405/00 (2006.01) C07D 311/94 (2006.01)

Patent

CA 2637797

Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2- oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.

L'invention porte sur une méthode de préparation d'un dérivé de prostaglandine de formule (A) consistant à faire réagir un aldéhyde de formule (I) avec un 2-oxoalkyl phosphonate dans un solvant de réaction, en présence d'un hydroxyde alcalin formant la seule base. L'utilisation de l'hydroxyde alcalin comme seule base dans le système réactif permet d'obtenir ledit dérivé par des procédures simples et avec un fort rendement.

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