Method for preparing pyrimidin-2-ylacetic acid esters

Details Method for preparing pyrimidin-2-ylacetic acid esters Method for preparing pyrimidin-2-ylacetic acid esters

C - Chemistry, Metallurgy

07

D

C07D 239/52 (2006.01) C07D 239/26 (2006.01)

Patent

CA 2209258

A method is described for preparing pyrimidin--2-ylacetic acid esters of the general formula: Image wherein R is C1-6-alkyl, C3-6-cycloalkyl, aryl or arylalkyl and R1 to R3, independently of one another, each represent hydrogen, C1-6-alkyl, fluorinated C1-6-alkyl, C1-6-alkoxy, (C1-6- alkoxy) -C1-6-alkyl or (C1-6-alkoxy) carbonyl. The esters I are obtained from the corresponding 2-(halomethyl)pyrimidine, the corresponding alcohol ROH and carbon monoxide in the presence of a palladium-phosphine complex and a base. The pyrimidin--2-ylacetic acid esters are intermediates in the preparation of herbicides.

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