Method for preparing ( )r-2-methyl-hexane-1,2-diol

Details Method for preparing ( )r-2-methyl-hexane-1,2-diol Method for preparing ( )r-2-methyl-hexane-1,2-diol

C - Chemistry, Metallurgy

07

C

260/635.5

C07C 31/20 (2006.01) C07C 59/115 (2006.01)

Patent

CA 1265819

ABSTRACT OF THE DISCLOSURE A method for preparing important stereospecific intermediates in the synthesis of prostaglandin analogs is disclosed. Said intermediates are (+)R-2-methyl-hexane-1,2-diol and (-)S-2-methyl- -hexane-1,2-diol and are prepared via an asymmetric halolactonization reaction utilizing L-proline and D-proline, respectively as the chiral agent. MS-1386-CIP

505409

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