Method for preparing (r)- (+) -3 {1- ¬2-( 4-benzoyl- 2-(3,4-...

Details Method for preparing (r)- (+) -3 {1- ¬2-( 4-benzoyl- 2-(3,4-... Method for preparing (r)- (+) -3 {1- ¬2-( 4-benzoyl- 2-(3,4-...

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) C07D 265/30 (2006.01)

Patent

CA 2351539

The invention concerns a method for preparing (R) -(+)- 3{1- [2-(4 -benzoyl-2- (3,4-difluorophenyl)morpholin -2-yl}ethyl]- 4-phenylpiperidin- 4-yl]-1,1- dimethylurea, its salts solvates and/or hydrates, of formula (I), intermediate compounds and succinate and fumarate of (R)- (+)-3{1- [2-(4-benzoyl- 2-(3,4- difluorophenyl)morpholin- 2-yl)ethyl]-4- phenylpiperidin-4- yl}-1,1- dimethylurea.

Un procédé de préparation du (R)- (+)-3-{1-[2- (4-benzoyl-2-(3,4- difluorophényl)morpholin-2- yl)éthyl]-4-phénylpipéridin-4- yl}-1,1-diméthylurée, de ses sels, solvats et/ou hydrates, de composés intermédiaires et enfin du succinate et du fumarate de (R)-(+)- 3-{1-[2-(4-benzoyl- 2-(3,4-difluorophényl)morpholin- 2-yl)éthyl]-4-phénylpipéridin- 4-yl}- 1,1-diméthylurée.

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